Are you having a pop up, or is the game just crashing to the desktop without a message?
Ensuring your Mother Base progress isn't lost during a reinstall. How to Properly Patch Your Game
In Steam, right-click the game > Properties > Local Files > Verify integrity of game files . This replaces any corrupted "3dm" or "cpy" files that might be causing conflicts.
One of the most notorious bugs where the game window opens to a white screen and immediately closes. This is often linked to CPU architecture (specifically older AMD processors) or outdated DirectX files.