: Pixel Game Maker MV requires specific Microsoft Visual C++ packages. You must have VC2010, VC2012, VC2013, and VC2015 installed.
: Unplug secondary monitors, launch the software once, and then reconnect them.
Manually delete the remaining folder in Steam/steamapps/common/Pixel Game Maker MV to clear corrupted files. Reinstall the program.
If your game runs but won't enter fullscreen or suffers from "tearing" when it does, adjust these settings: