The original series finale that provided a bittersweet conclusion to the Burrows-Scofield saga.

The intense escape from the "unbreakable" Sona prison in Panama.

One of the most effective series premieres ever made, perfectly setting up the high-stakes premise.

Commonly cited by fans and critics as the single greatest episode of the series, is the long-awaited culmination of Michael Scofield’s "Fox River" plan. After twenty episodes of meticulous preparation, the "Fox River Eight" finally make their move through the hole in Michael's cell.

We see the different paths each escapee takes—from T-Bag seeking a veterinarian to reattach his hand to the tragic death of Veronica Donovan. IMDb Rating: 8.8/10 Honourable Mentions

This legendary two-parter showcased the show's ability to balance complex puzzles with visceral action. To gain the time needed to drill a hole behind his cell, Michael provokes a prison-wide lockdown that spirials into a full-scale riot.

Transitioning from a prison drama to a cross-country manhunt was a risky move, but the Season 2 premiere, executed it perfectly.

Just as they believe they've won, a major betrayal by Agent Self flips the entire season on its head. IMDb Rating: 9.0/10 5. " Manhunt " (Season 2, Episode 1)